Product Name: RXON Active Vitamin B12
Ingredients: xylitol, methylcobalamin (co-methylcobalamin) (active vitamin B12), maltodextrin, corn starch, microcrystalline cellulose
Suggested dosage: 1 capsule each time, 1 time a day
Suitable crowd: Adult
Note: Do not eat desiccant
Storage method: Store in a cool and dry place, avoid direct sunlight, keep away from children
Production date: See bottle (month/day/year)
Shelf life: 36 months
Country of origin: United States
Specification: 63g (1g X 63 grains)
Vitamin B12, also called cobalamin, is a polycyclic compound containing trivalent cobalt. 4 reduced pyrrole rings are joined together to become a corrin macrocycle (similar to porphyrin), which is the only metal containing Elements of vitamins. Vitamin B12 is a red crystalline powder, odorless and tasteless, slightly soluble in water and ethanol, most stable under pH 4.5-5.0 weak acid conditions, decomposed in strong acid (pH<2) or alkaline solution, and may be damaged to a certain extent when exposed to heat . Higher animals and plants cannot produce vitamin B12. Vitamin B12 in nature is synthesized by microorganisms. Vitamin B12 is the only vitamin that needs the help of intestinal secretions (endogenous factors) to be absorbed. It participates in the production of bone marrow red blood cells, prevents pernicious anemia, and prevents brain nerves from being damaged.
B12 is mainly found in meat. Soybeans in plants and some herbs also contain B12, which can be synthesized by intestinal bacteria, so it is not lacking under normal circumstances. However, B12 is a vitamin that people with digestive tract diseases are prone to lack, and it is also indispensable for red blood cell production. Important elements, if severely lacking, will lead to pernicious anemia!
Vitamin B12 is widely present in animal food. And its form cannot be absorbed by the human body. In addition, vitamin B12 is also the only vitamin that contains essential minerals. It is red due to the cobalt content. It is also called red vitamin and is one of the few colored vitamins. Although vitamin B12 belongs to the B group vitamins, it can be stored in the liver. After the storage is exhausted, it will take more than half a year for the symptoms of deficiency to appear. The human body needs very little vitamin B12, as long as the diet is normal, it will not be lacking. A small number of people with malabsorption should pay special attention.
Absorption and metabolism
Vitamin B12 in food is combined with protein and enters the human digestive tract. Under the action of gastric acid, pepsin and trypsin, vitamin B12 is released and binds to a glycoprotein intrinsic factor (IF) secreted by gastric mucosal cells. Vitamin B12-IF complex is absorbed in the ileum. The storage of vitamin B12 is very small, about 2~3mg in the liver. It is mainly excreted from urine and partly from bile.
There are two main ones: ① As a cofactor of methyltransferase, it participates in the synthesis of methionine and thymine, such as the conversion of methyltetrahydrofolate to tetrahydrofolate and the transfer of methyl groups to methyl receptors (like semi- Cystine), the methyl acceptor becomes a methyl derivative (such as methionine or methyl homocysteine), the reaction is shown in the figure. Therefore, vitamin B12 can promote protein biosynthesis, and affect the growth and development of infants and young children when it is lacking. ② Protect the transfer and storage of folic acid in cells. When vitamin B12 is deficient, the folate content of human red blood cells is low, and the folate stored in the liver is reduced. This may be related to the lack of vitamin B12, which causes difficulty in transferring methyl groups from homocysteine to methionine, and methyl groups accumulate in cells and damage The storage of tetrahydrofolate in the cell is affected, because tetrahydrofolate has a strong tendency to combine with methyl to form methyltetrahydrofolate, which synthesizes polyglutamic acid.
The main function
1. Promote methyl transfer
2. Promote the development and maturation of red blood cells, keep the body's hematopoietic function in a normal state, prevent pernicious anemia; maintain the health of the nervous system
3. In the form of coenzyme, it can increase the utilization rate of folic acid and promote the metabolism of carbohydrates, fats and proteins.
4. It has the function of activating amino acids and promoting the biosynthesis of nucleic acid, which can promote the synthesis of protein, which plays an important role in the growth and development of infants and young children.
5. Metabolize fatty acids, so that fat, carbohydrates, and protein are properly used by the body
6. Eliminate irritability, concentrate attention, enhance memory and sense of balance
7. It is an indispensable vitamin for the healthy function of the nervous system and participates in the formation of a lipoprotein in the nervous tissue
One is to improve the utilization of folic acid, synthesize methionine (synthesized from homocysteine) and choline together with folic acid, and synthesize cyanocobalamin precursors such as methylcobalamin and coenzyme during the process of producing purines and pyrimidines. B12, involved in the methylation process of many important compounds. When vitamin B12 is deficient, the activity of transferring methyl groups from methyltetrahydrofolate is reduced, making folic acid into an unusable form, leading to folic acid deficiency.
The second is to maintain the metabolism and function of the nerve myelin sheath. When vitamin B12 is lacking, it can cause neurological disorders, spinal cord degeneration, and can cause severe mental symptoms. Vitamin B12 deficiency can cause peripheral neuritis. The early manifestations of a child's vitamin B12 deficiency are abnormal mood, sluggish expression, unresponsiveness, and finally anemia.
The third is to promote the development and maturation of red blood cells. Methylmalonyl-CoA is converted into succinyl-CoA, which participates in the tricarboxylic acid cycle, and succinyl-CoA is related to the synthesis of heme.
Fourth, vitamin B12 is also involved in the synthesis of deoxynucleic acid (DNA), the metabolism of fats, carbohydrates and proteins, and increases the synthesis of nucleic acids and proteins.
Mecobalamin can relieve the symptoms of dizziness, fatigue, lack of appetite, symmetrical numbness of hands and feet caused by anemia in patients with megaloblastic anemia. It has the function of nourishing nerves and can alleviate the typical symptoms of patients with peripheral neuropathy, including facial sensitivity, pain, numbness, tingling, muscle weakness and muscle atrophy in the feet or hands. Occasionally gastrointestinal adverse reactions: loss of appetite, nausea, vomiting, diarrhea, etc.; "treatment of peripheral neurological diseases and anemia. Methylcobalamin is actually a derivative of vitamin B12, which has the function of repairing and nourishing nerves, so it is mainly used For the treatment of peripheral neurological diseases, it can also be used for anemia caused by vitamin B12 deficiency.
【feature of product】
1. Nourish nerves. Vitamin B12 has nourishing nerves and promotes the repair of nerve fibers. Widely used in various neurological diseases, including cerebral hemorrhage, cerebral infarction, transient ischemic attack, facial nerve palsy, spinal cord disease, demyelinating disease, peripheral neuropathy, Alzheimer's disease, Parkinson's disease, autonomic nerve Dysfunction, etc.
2. To correct anemia, vitamin B12 is often combined with folic acid to treat megaloblastic anemia, and it is mostly used to treat patients with anemia after most gastrectomy.
3. Promote sleep. Vitamin B12 also has the effect of inducing sleep, improving sleep quality and reducing the symptoms of dreaminess.
4. Vitamin B12 also has the effect of relieving the soreness and dryness of the eyes.