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RXON Silymarin

RXON Silymarin

Product Name: RXON Silymarin
Ingredients: Silymarin, Inulin, Curcumin
Each capsule contains: silymarin 400 mg, inulin 100 mg, turmeric 50 mg
Suggested Dosage: 1 capsule daily, taken with meals or as directed by your healthcare practitioner
Edible limit: inulin ≤ 15 g/day
Suitable crowd: Adult
Note: Not suitable for infants and young children
Storage method: Store in a cool and dry place, avoid direct sunlight
Production date: See bottle (month/day/year)
Shelf life: 36 months
Country of origin: United States
Specification: 42g (0.7g×60 grains)

Product description

RXON Silymarin (http://www.wrxon.hk/)  第1张

 

Silymarin, a natural flavonoid lignan compound, is a natural active substance extracted from the dried fruit of the Compositae plant Silymarin. Its main components are silybin and iso Silybin (isosilybim), silydianin (silydianin) and silychristin (silychristin). Silymarin is insoluble in water, soluble in acetone, ethyl acetate, methanol ethanol, and slightly soluble in chloroform.

effect

The substance has the following effects: protect liver cells from toxic substances, especially alcohol and environmental pollutants (pesticides, heavy metals, etc.) invade and damage the liver; it has a strong antioxidant function, which can protect liver cells from free radical damage, and is effective Far better than vitamin E; promote protein synthesis, speed up the production of new liver cells, or make damaged liver cells repair themselves. Therefore it is called "natural hepatoprotective medicine". In addition, silymarin has the effects of anti-radiation, anti-aging, preventing arteriosclerosis, and delaying skin aging. This product is widely used in the production of medicines, health products, cosmetics, food and other products. The current dosage forms of silymarin include oral preparations: silymarin tablets, Yiganling tablets, silybin lecithin complex hard capsules. The product names are: Liganlong, Lijialong, Yiganling and so on. Injections are mainly made into silibinin derivatives, such as portugal-N·methylamine salt.

Silymarin 2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-hydroxymethyl-6-(3,5,7-trihydroxy-4-oxobenzopyran) -2-yl) benzodioxane

Silymarin (Silymarin) refers to a class of flavonoid lignans formed by condensation of dihydroflavonols and phenylpropion derivatives from the fruits and seeds of the compositae herb Silybum marinaum (L) Gaenrt] Ingredients. The total flavonoid lignans in silymarin (trade name: Lijialong, Yiganling and Milk Thistle, etc.) currently used in international preparations are about 80%, and it mainly contains silybin (silibinin). , Isosilybin (isosilybin, isosilibinin), siliehristin (siliehristin), silidinain (silidinain) four isomers, of which silybin has the highest amount and has the highest hepatoprotective activity.

Function

This product has an inhibitory effect on lipoxygenase and peroxidase. It is clinically used for the treatment of liver poisoning, liver dysfunction, anti-radiation and hypolipidemic effect.

A large number of studies have shown that silymarin and silybin compounds have a wide range of pharmacological activities. The main activities are summarized as follows:

Scavenging reactive oxygen species

Directly remove reactive oxygen species, resist lipid peroxidation, and maintain the fluidity of cell membranes;

Hepatoprotective effect

Silymarin has a protective effect on liver damage caused by carbon tetrachloride, galactosamine, alcohols and other liver toxins;

Anti-tumor effect

Various reactive oxygen species can oxidize guanine to form 8-antylguanine, which can cause DNA damage and cause tumors. The application of antioxidants, especially free radical scavengers, can prevent this process from occurring;

Anti-cardiovascular disease effect

Ksoottva et al. studied the effect of milk thistle extract on the oxidation of high cholesterol and low-density lipoproteins in mice. The mice were fed with polyunsaturated fatty acids and a small amount of saturated fatty acids in the water-containing silymarin extract, compared with feeding polyunsaturated fatty acids and In mice fed with a small amount of saturated fatty acids, the cholesterol content in the serum of the former was significantly reduced, VLDL hair was reduced, and HDL-C increased, indicating that silymarin increased the ability of anti-LDL;

Protects against cerebral ischemia injury

Feng Quan et al. used the four-vessel block method to create a rat model of global cerebral ischemia to explore the mechanism of the protective effect of silymarin on cerebral ischemic injury. By observing the expression of silymarin on the expression of nitric oxide and nitric oxide synthase in brain homogenate, It showed that silymarin significantly reduced the content of NO and NOS in the brain tissue of ischemic rats, and at the same time significantly reduced the infarct area. Therefore, it is concluded that silymarin can improve the body's antioxidant capacity and has a significant protective effect on cerebral ischemic injury.

Scope of application

It extends from the prevention and treatment of acute and chronic hepatitis to anti-aging and prevention and treatment of atherosclerosis. It is clinically used in acute and chronic hepatitis, early cirrhosis, toxic liver injury, etc.

This product has an inhibitory effect on lipoxygenase and peroxidase. It is clinically used for the treatment of liver poisoning, liver dysfunction, anti-radiation and hypolipidemic effect.

A large number of studies have shown that silymarin and silybin compounds have a wide range of pharmacological activities. The main activities are summarized as follows:

1 Remove active oxygen

Directly remove reactive oxygen species, peroxidize lipids, and maintain the fluidity of cell membranes;

2 Hepatoprotective effect

Silymarin has a protective effect on liver damage caused by carbon tetrachloride, galactosamine, alcohols and other liver toxins;

3 Anti-tumor effect

Various reactive oxygen species can oxidize birds to float to form 8-antelope bird noises, which can cause DNA damage and cause tumors. The application of antioxidants, especially free radical scavengers, can prevent this process from happening;

4 Anti-cardiovascular disease effect

Ksoottva et al. studied the effect of milk thistle extract on the oxidation of high cholesterol and low-density lipoproteins in mice. The mice were fed with polyunsaturated fatty acids and a small amount of saturated fatty acids in the water-containing silymarin extract, compared with feeding polyunsaturated fatty acids and In mice fed with a small amount of saturated fatty acids, the cholesterol content in the serum of the former was significantly reduced, VLDL hair was reduced, and HDL-C increased, indicating that silymarin increased the ability of anti-LDL;

5 Protects against cerebral ischemia injury

Feng Quan et al. used the four-vessel block method to create a rat model of global cerebral ischemia to explore the mechanism of the protective effect of silymarin on cerebral ischemic injury. By observing the expression of silymarin on the expression of nitric oxide and nitric oxide synthase in brain homogenate, It showed that silymarin significantly reduced the content of NO and NOS in the brain tissue of ischemic rats, and at the same time significantly reduced the infarct area. Therefore, it is concluded that silymarin can improve the body's antioxidant capacity and has a significant protective effect on cerebral ischemic injury.

Curcumin

Curcumin is a natural compound with good anti-inflammatory and anti-cancer properties. Curcumin is a diketone compound extracted from the rhizomes of some plants in the Zingiberaceae and Araceae family. The chemical formula is C21H20O6. Among them, turmeric contains about 3% to 6% curcumin, which is a rare pigment with a diketone structure in the plant kingdom. Curcumin is an orange-yellow crystalline powder with a bitter taste and insoluble in water. It is mainly used for coloring intestinal products, canned food, and sauce products in food production. Curcumin has the effects of lowering blood lipids, anti-tumor, anti-inflammatory, choleretic, and antioxidant. In addition, some scientists have found that curcumin can help treat drug-resistant tuberculosis.

Inulin

Inulin is contained in the protoplasm of the cell in the form of a colloid. Unlike starch, it is easily soluble in hot water and precipitates out of water when ethanol is added. It does not react with iodine. Moreover, inulin is very easy to hydrolyze fructose under dilute acid, which is the characteristic of all fructans. Fructose can also be hydrolyzed by inulase. Both humans and animals lack the enzymes that break down inulin.

Inulin is another form of energy storage for plants in addition to starch. It is an ideal functional food ingredient and a good raw material for the production of oligofructose, polyfructose, high fructose syrup, crystalline fructose and other products.

Work effect

1. Control blood lipids

Intake of inulin can effectively reduce serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), increase the ratio of high-density lipoprotein/low-density lipoprotein, and improve blood lipid status. Hidaka et al. reported that elderly patients aged 50-90 who consumed 8g of short-chain dietary fiber daily reduced the levels of triglycerides and total cholesterol in the blood after two weeks. Yamashita et al. gave 18 diabetic patients 8g of inulin for two weeks, and the total cholesterol was reduced by 7.9%, but HDL-cholesterol remained unchanged. The above-mentioned parameters did not change in the control group fed with food. Brighenti et al. observed that when 12 healthy young men added 9g of inulin to their daily breakfast cereals for 4 weeks, total cholesterol was reduced by 8.2%, and triglycerides were significantly reduced by 26.5%.

Many dietary fibers absorb fat in the intestines to form a fat-fiber complex that is excreted in the feces, thereby reducing blood lipid levels. Moreover, inulin is fermented into short-chain fatty acids and lactate by itself before the end of the intestine, and lactate is a regulator of liver metabolism. Short-chain fatty acids (acetate and propionate) can be used as fuel in the blood, and propionate inhibits the synthesis of cholesterol.

2. Lower blood sugar

Inulin is a carbohydrate that does not cause an increase in glucose in the urine. It will not be hydrolyzed into monosaccharides in the upper part of the intestine, so it will not increase blood sugar levels and insulin content. Research now shows that the reduction of fasting blood glucose is the result of short-chain fatty acids produced by the fermentation of oligofructose in the colon.

3. Promote the absorption of minerals

Inulin can greatly improve the absorption of Ca2+, Mg2+, Zn2+, Cu2+, Fe2+ and other minerals. According to reports, teenagers consumed 8 g/d (long and short-chain inulin-type fructans) for 8 weeks and 1 year, respectively, and found that both significantly increased the absorption of Ca2+, and the body's bone mineral content and density also increased significantly.

The main mechanisms of inulin to promote the absorption of mineral elements are: 1) The short-chain fat produced by inulin in the colon makes the crypts on the mucous membrane shallow, and the number of crypt cells increases to increase the absorption area, and the cecal veins are more developed. 2) The acid produced by fermentation lowers the pH of the colon, which improves the solubility and bioavailability of many minerals. In particular, short-chain fatty acids can stimulate the growth of colonic mucosal cells and increase the absorption capacity of the intestinal mucosa; 3) Inulin can promote Some microorganisms secrete phytase, which can release the metal ions chelated with phytic acid and promote its absorption. 4) Some organic acids produced by fermentation can chelate with metal ions to promote the absorption of metal ions.

4. Regulate intestinal microflora, improve intestinal health and prevent constipation

Inulin is a natural water-soluble dietary fiber, which can hardly be hydrolyzed and digested by gastric acid. It is only used by beneficial microorganisms in the colon to improve the intestinal environment. Studies have shown that the degree of proliferation of bifidobacteria depends on the number of initial bifidobacteria in the human large intestine. When the initial number of bifidobacteria decreases, the proliferation effect is obvious after using inulin. When the initial number of bifidobacteria is large, use chrysanthemum The effect after powder is not obvious. Secondly, the intake of inulin can enhance gastrointestinal motility, improve gastrointestinal function, increase digestion and appetite, and improve immunity.

5. Inhibit the production of toxic fermentation products, protect the liver and prevent colon cancer

Food reaches the colon after digestion and absorption. Under the action of intestinal saprophytes (E. coli, Bacteroides, etc.), many toxic metabolites (such as ammonia, nitrosamines, phenol and cresol, secondary bile acids, etc.) can be produced ), and the short-chain fatty acids produced by the fermentation of inulin in the colon can lower the pH of the colon, inhibit the growth of saprophytes, reduce the production of toxic products, and reduce the stimulation of the intestinal wall. A series of metabolic activities of inulin can inhibit the production of toxic substances, increase the frequency and weight of bowel movements, increase the acidity of feces, accelerate the excretion of carcinogens, and produce short-chain fatty acids with anti-cancer effects, which is beneficial to the prevention of colon cancer.

6. Prevent constipation and treat obesity. Dietary fiber reduces the residence time of food in the gastrointestinal tract and increases the amount of feces to effectively treat constipation. Its weight loss effect is to increase the viscosity of the contents and reduce the speed of food from the stomach to the small intestine, thereby reducing hunger and reducing food intake.

7. There are a small amount of 2-9 oligofructose in inulin. Studies have shown that oligofructose can increase the expression of trophic factors in brain nerve cells, have a good protective effect on corticosterone-induced neuronal damage, and have good resistance Depressive effect.

feature of product

Natural herb extraction technology
High content and high purity
It is mainly suitable for acute hepatitis, chronic hepatitis, early liver cirrhosis, fatty liver, toxic liver damage, such as taking a certain specific drug or drinking a lot of alcohol on a regular basis, which can damage the liver cells, and has the function of protecting the liver.

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